pyroglutamic acid การใช้

• Glutamine is converted to glutamic acid or pyroglutamic acid ( 5-oxoproline ).
• In the presence of bacteria with pyrrolidonyl peptidase, it is broken down to pyroglutamic acid and 2-naphthylamine.
• Thus its metabolic route is exactly parallel to that of piracetam, aniracetam, phenylpiracetam, and all other members of the-racetam family, and also pyroglutamic acid.
• As a free amino acid, or as the N-terminal residue of a peptide or protein, glutamine deamidates readily to form pyroglutamic acid ( 5-oxoproline ).
• Because the Edman degradation proceeds from the N-terminus of the protein, it will not work if the N-terminus has been chemically modified ( e . g . by acetylation or formation of Pyroglutamic acid ).